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Technology Overview

One System, Many Applications

The Palladium™ System provides a cost effective solution for identifying disease or biological threats in resource limited environments. While the device is compact, rugged and portable, the real breakthrough is in the disposable cartridge. The sample preparation and diagnostic cartridge fully automate processes and reduces time, cost and resources.

Time Equipment
Reduce Time Provides results in minutes, not hours or days.
Reduce Cost Lowers the cost per test significantly; processed on equipment that costs 1/10 that of other "mobile" systems.
Reduce Resources Does not require highly trained health care workers; integration and automation puts testing quickly in the hands of the soldier, ranch hand or clinic tech.

The Palladium™ System is based on several key, proprietary enabling technologies:

  1. Fluidics
  2. Sample Preparation
  3. Electronic Detection
  4. Networking

Fluidics

Integrated Nano-Technologies (INT) unique cartridge design uses a disposable, injection-molded cartridge to clean and concentrate contaminated samples for identification. The cartridge automates multiple laboratory processes, streamlining equipment and process time:

  • Reagent storage and valving
  • Heating
  • Sonication/mixing
  • Magnetic separation
  • Filtration
  • Desalting/column purification
The novel design allows for flexibility in the number and order of steps performed in the cartridge.

Sample Preparation

INT's sample preparation approach allows for the broadest range of inputs. The sample is disrupted and DNA and RNA are sheared in a single step using ultrasonics for the highest yield. Magnetic particles capture and manipulate the nucleic acid molecules. The process is 95% efficient, and can be used for:

  • Electronic detection
  • PCR
  • RT-PCR
  • Gene sequencing
Electronic Detection

DNA and RNA bridges are formed with the target nucleic acid between two electrodes; these bridges are metallized then electrically detected.

Networking

INT's global disease surveillance capability is critical to helping our customers better manage resources and proactively manage disease. The Palladium™ System is designed to:

  • Wirelessly report data to a secure central site
  • Automatically alert your workers, WHO or other designated officials of positives
  • Link with surveillance programs to improve modeling
  • Provide continuous feedback between all data systems, allowing you to reassign resources proactively
The Palladium™ System utilizes GPS and Google Earth technology to map results real-time.